MURINE LEUKEMIA VIRUS P12 TETHERS THE CAPSID-CONTAINING PRE-INTEGRATION COMPLEX TO CHROMATIN BY BINDING DIRECTLY TO HOST NUCLEOSOMES IN MITOSIS.

Murine leukemia virus p12 tethers the capsid-containing pre-integration complex to chromatin by binding directly to host nucleosomes in mitosis.

The murine leukaemia virus (MLV) Gag cleavage product, p12, is essential for both early and late steps in viral replication.The N-terminal domain of p12 binds directly to capsid (CA) and stabilises the mature viral core, whereas defects in the C-terminal domain (CTD) of p12 can be rescued by addition of heterologous chromatin binding sequences (CBS

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Loss-of-function mutations in Rab escort protein 1 (REP-1) affect intracellular transport in fibroblasts and monocytes of choroideremia patients.

BACKGROUND: Choroideremia (CHM) is a progressive X-linked retinopathy caused by mutations in the CHM gene, which encodes Rab escort protein-1 (REP-1), an escort protein involved in the prenylation of Rabs.Under-prenylation of certain Rabs, as a result of loss of function mutations in REP-1, could affect vesicular trafficking, exocytosis and secreti

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Ground subsidence and heave over permafrost: hourly time series reveal interannual, seasonal and shorter-term movement caused by freezing, thawing and water movement

Heave and subsidence of the ground surface can offer insight into processes of heat and mass transfer in freezing and thawing soils.Additionally, subsidence is an important metric for monitoring and understanding the transformation of permafrost landscapes under climate change.Corresponding ground observations, however, are sparse and episodic.A si

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Pengaruh Latihan Core Stability Statis (Plank dan Side Plank) dan Core Stability Dinamis (Side Lying Hip Abduction dan Oblique Crunch) Tterhadap Keseimbangan

The purpose of this study is to analyze about: (1) the effects of exercise Course a pied - Accessoires - Nutrition Plank to the increase in the balance; (2) Side Plank exercise influence on the balance; (3).Side effects of exercise on the balance Lying Hip Abduction; (4).Oblique Crunch exercise influence on the balance; and (5) differences in the e

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